Type 2 diabetes mellitus is a fast-growing epidemic affecting people globally. Some clinical studies used 200 to 400 mg (extracted from the root or tuber) by mouth per day. This item: Kudzu Alcohol-Free Liquid Extract, Organic Kudzu (Pueraria lobata) Dried Root Glycerite Hawaii Pharmâ¦ $24.95 ($12.48 / 1 Fl Oz) In Stock. You should talk with your health care provider for complete information about the risks and benefits of using this product. The Chinese Pueraria root extract (Pueraria lobata) ameliorates impaired glucose and lipid metabolism in obese mice. It contains around 20 species of herbaceous or woody vines, all native to Asia. Gluten Free! 12. Examine.com and its Editors do not advocate nutritional supplementation over proper medical advice or treatment and this sentiment will never be expressed through pages hosted under Examine.com. All factual claims are followed by specifically-applicable references. For breast enlargement, manufacturers suggest a twice-daily topical application to the breast area for 3 to 5 minutes until fully absorbed. Click here to see the full set of references At Examine.com, our incentives line up with yours — getting unbiased information. The mechanism underlying anti-obesity effect of RP was investigated in high-fat diet (HFD) induced obese mice and skeletal muscle cells (C2C12). No significant alterations in luteinizing hormone has been detected with pueraria lobata ingestion. Pueraria Mirifica (same genera, different herb), Japanese Knotweed (also called Kudzu), Angelica dahurica (enhances absorption of Puerarin from Pueraria Lobata), Savlia Miltiorrhiza (Danshen) for anti-inflammatory purposes. For topical products, manufacturers suggest a twice-daily topical application to the breast area for 3 to 5 minutes until fully absorbed. Pueraria lobata. Bonus: unlock the supplement Human Effect Matrix and all health topics on Examine.com. Botanical Name: Pueraria lobata. This information relates to an herbal, vitamin, mineral or other dietary supplement. Available for Android and iOS devices. Efficacy and Safety of Pueraria lobata Extract in Gray Hair Prevention: A Randomized, Double-Blind, Placebo-Controlled Study. Avoid use during pregnancy and lactation because of the lack of clinical data and the plant's phytoestrogen activity. Pueraria Lobata Root Extract Applications: 1. Because of its phytoestrogen-like effects, use pueraria with caution if diagnosed with an estrogen-dependent neoplasia, pulmonary embolism, liver dysfunction or disease, or anemia. Most commercial products containing pueraria are available as rejuvenating, antiaging, or skin-lightening creams or gels, as beauty soaps, or as capsules or tablets for increasing appetite, enlarging breasts, modulating hair growth or regrowth, and other rejuvenating purposes. Kudzu Root Extract. 1-4-2005;96(1-2):133-138. In sex-hormone–deficient male rats, treatment with P. mirifica root powder completely inhibited bone loss in long bones and axial bones. mirifica decreased neuronal cell death in a time- and dose-dependent manner against neurotoxic agents in an Alzheimer disease model in vitro.Sucontphunt 2007, Sawatsri 2004 Mechanism of action may be associated with an effect on synaptic density by inducing synaptophysin expression via estrogen receptor.Chindewa 2008, Spinasterol, an active cytotoxic component of P. mirifica, was active against certain gynecological cancer cell lines and activates estrogen receptors ER-alpha and ER-beta. A small boost in cognition in menopausal women given the supplement; needs to be replicated and uncertain if it applies to otherwise healthy youth. Pueraria mirifica is sometimes used as an anti-aging supplement or as a natural remedy for menopausal symptoms such as hot flashes and vaginal dryness. Suvatabhandu.Common Name(s): Kwao Keur, Kwao Krua, Kwao Kruea, White Kwao Krua. Highest Strength Kudzu liquid extract! extract of pueraria lobata, pueraria lobata (kudzu) root extrac, pueraria lobata (kudzu) root extract, pueraria lobata extract, and pueraria lobata root extract Cancer Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments. That's why we don’t sell any advertising or supplements. This information is not specific medical advice and does not replace information you receive from your health care provider. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. Most commercial products containing pueraria are available as rejuvenating, antiaging, or skin-lightening creams or gels, as beauty soaps, or as capsules or tablets for increasing appetite, enlarging breasts, modulating hair growth or regrowth, and other rejuvenating purposes. This page features 32 references. December 2020; BMC Complementary Medicine and Therapies 20(1) DOI: 10.1186/s12906-020-02998-1. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age. It increased luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in both sexes.Malaivijitnond 2004 The mechanism of action involved direct stimulation of the accessory sex organs and suppression of the hypothalamic-pituitary-gonadal axis. Our evidence-based analysis on pueraria lobata features About the Experts. This is only a brief summary of general information about this product. We have a strict editorial process. The report provides an understanding of the global Pueraria Lobata Root Extract industry competitors, â¦ Radix Pueraria lobata (RP) has been reported to prevent obesity and improve glucose metabolism; however, the mechanism responsible for these effects has not been elucidated. The benefits of Pueraria are seemingly endless; some people use it to alcoholism, heart and circulatory problems, upper respiratory problems, and skin problems. https://examine.com/supplements/pueraria-lobata/, © 2011-2020 Examine.com Inc | Privacy | Terms of Service | Disclaimer | About Us | Contact Examine.com, Small boost in attention in menopausal women (independent of reductions in symptoms of menopause); needs to be reinvestigated. Results indicated that P. lobata exhibited high PTP1B inhibitory activity with IC 50 of â¦ She is known worldwide as The Cosmetics Cop and creator of Paulaâs Choice Skincare. It is unsure if this is near the optimal dosage or not. Kudzu (Pueraria lobata) is one of the earliest medicinal plants used in traditional Chinese medicine. J Pharmacol Sci 2004;96:420-7. Toxicol Appl Pharmacol 2005;209:263-8. Rating: Best; Categories: Antioxidants, Plant Extracts; See kudzu root Back to Ingredient Dictionary. Because of pueraria's estrogen-like effect, use with caution in patients with asthma, diabetes mellitus, epilepsy, migraine, or systemic lupus erythematosus. 32 unique references to scientific papers. Arm yourself with the knowledge you need to make the right decisions about your health. No alterations in Apolipoprotein B have been noted, No significant influence of Pueraria lobata on circulating estrogen levels (although it itself may be a phytoestrogen; weak). No significant alterations have been noted in follicle-stimulating hormone concentrations following pueraria lobata ingestion. the roots and flowers of kudzu, Radix and Flos puerariae, respectively, have been used to treat alcohol abuse safely and effectively in China for more than a millennium. We are 100% backed by science. This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. Its ingredients are isoflavonoids, tripenoids, coumarins, etc. The main ingredient of Pueraria extract. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. The tuberous roots of P. mirifica primarily contain the active component miroestrol and its derivative, deoxymiroestrol.Chansakaow 2000 The tuberous roots of P. mirifica also contain daidzin, daidzein, genistin, genistein, puerarinIngham 1986 mirificoumestan, kwakhurinIngham 1986, Tahara 1987 coumestrolIngham 1988 mirificin, and 2 steroids, estrone and estriol.Sookvanichsilp 2008, Ingham 1986, Ingham 1989, Chansakaow 2000 The manufacture and synthesis of miroestrol is documented.Corey 1993, Ishikawa 2006 Deoxymiroestrol was isolated and identified as the most active phytoestrogen of the plant.Cherdshewasart 2004, Sookvanichsilp 2008, Ishikawa 2001. Jo SJ, Shin H, Paik SH, et al. to see the full set of research information and references for Pueraria lobata. Increased triglyceride levels may occur.Manonai 2008, Because of the estrogen-like effect of P. mirifica, use with caution in patients with asthma, diabetes mellitus, epilepsy, migraine, or systemic lupus erythematosus. Serum FSH, LH, estradiol, progesterone, and immunoreactive-irinhibin were lower in a dose-dependent manner during treatment. View abstract. Become an Examine.com member to get access to the latest research. At higher doses, it increased bone density without affecting accessory sex organs.Urasopon 2007 In a similar study, P. mirifica completely inhibited bone loss in long bones and axial bones in estrogen-deficient female rats.Urasopon 2008 However, the highest dose of P. mirifica root powder (1,000 mg/kg body weight per day) caused an undesired adverse reaction of increased uterine weight. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect. The team includes nutrition researchers, registered dietitians, physicians, and pharmacists. Become an Examine Personalized member to access the latest nutrition research on over 400 supplements across more than 600 different health goals, outcomes, conditions, and more. The medical literature documents the plant's use primarily for menopause, but also for cancer and osteoporosis. What makes it difference is the amount of its active compound called Phytoestrogen. A comparative study on aqueous root extracts of Pueraria thomsonii and Pueraria lobata by antioxidant assay and HPLC fingerprint analysis. Commercial products are available in topical (creams, gels, and soaps) or oral (capsules or tablets) dosage forms. Pueraria mirifica is a plant native to Thailand and Burma. Enter your email and we'll keep you on top of the latest nutrition research, supplement myths, and more. Some of the isoflavonoids in P. mirifica had antioxidant activity similar to that of alpha tocopherol or vitamin E.Cherdshewasart 2008P. dietitians, physicians, and pharmacists. Kudzu Liquid Extract, Organic Kudzu (Pueraria lobata) Dried Root Tincture Features and description: NON GMO! HIGH or This information should not be used to decide whether or not to take this product. Study: The Chinese Pueraria root extract (Pueraria lobata) ameliorates impaired glucose and lipid metabolism in obese mice. Kudzu (Pueraria lobata) Root Extract 40% Flavonoids. Scientific Name(s): Pueraria mirifica Airy Shaw et. Each member of our research team is required to have no conflicts of interest, including with supplement The plant species P. mirifica (pueraria) belongs to the Fabaceae, or bean, subfamily, and its tuberous roots contain several phytoestrogens.Manonai 2007 P. mirifica is a woody vine commonly found in forests throughout ThailandMalaivijitnond 2006 with 28 cultivars presently documented. The estrogenic activity of kudzu and the cardioprotective effects of its constituent puerarin are also under investigation, but clinical trials are limited. Use with caution in patients with abnormal triglycerides or hypercalcemia. for this page. Studies in mice found that P. mirifica does not affect male fertility or the hypothalamus-pituitary-testis axis.Jaroenporn 2006 The testis, epididymis, and seminal vesicle all had normal histopathology in P. mirifica -treated male mice. Avoid use if hypersensitive to any of the components of product. The researchers suggest 1 mg of P. mirifica is equivalent to 0.52 to 0.75 mcg of ethinyl estradiol.Virojchaiwong 2011. 13. All factual claims are Get our free 5-day course on the essentials of supplementation. High Quality Kudzu liquid extract - we use classic conventional methods of â¦ Examine.com and its Editors do not ensure that unforeseen side effects will not occur even at the proper dosages, and thereby does not assume liability for any side effects from supplements or practices hosted under the domain of Examine.com. Pueraria Lobata Root Extract is an extract of the roots of Pueraria lobata, Fabacea 11. The plant's palmate-type leaves are simple or ovate and contain 3 leaflets in 1 petiole. Theoretically, drug interactions may occur with the following: May increase pharmacologic and toxicologic effects. The Human Effect Matrix summarizes human studies to tell you what effects It is applied in pharmaceutical field, pueraria isoflavones is widely used in biopharmaceuticals and API of cardiovascular system agents in China. In postmenopausal osteoporotic monkeys oral administration of P. mirifica improved both bone quality and quantity.Kittivanichkul 2016. The plant caused no changes in lipid profile or liver enzymes.Wattanapitayakul 2005 In male and female gonadectomized rats, P. mirifica had estrogen-like activity and affected accessory sex organs. Another component, known as PE-D, affected the growth in a dose-dependent and time-dependent manner on some breast cancer cell lines (MCF-7, MDAMB-231), and on the growth of ovarian (2774) and cervical cancer cells (HeLa).Baek 2003, Jeon 2005 The estrogenic effect of some components in P. mirifica has been compared with estradiol, a major estrogen in humans.Jeon 2005, Cherdshewasart 2008 The rank order of phytoestrogen potency is: deoxymiroestrol; miroestrol; 8-prenylnaringenin; coumestrol; genistein/equol; daidzein; resveratrol.Matsumura 2005P. It is applied in food field, pueraria isoflavones can lower blood pressure 2. there is, and how strong these effects are. During the posttreatment period, only monkeys treated with P. mirifica 10 and 100 mg/day of extract recovered from the changes in menstrual cycle length and hormone levels.Trisomboon 2005 Other studies document similar activity for the P. mirifica 1,000 mg/day dose of Trisomboon 2004 root extract and the direct correlation in dose with gonadotrophin levels.Trisomboon 2006, The plant had a dose-dependent estrogenic effect on rat vaginal cornification.Cherdshewasart 2007P. Buy Kudzu (Pueraria Lobata) Tincture, Organic Dried Roots Liquid Extract 2 oz on Amazon.com FREE SHIPPING on qualified orders Category. Thin-layer chromatography analysis has documented varying amounts of phytoestrogens collected from P. mirifica in different locations in Thailand.Malaivijitnond 2006, Cherdshewasart 2007 One of the challenges of large-scale manufacturing of P. mirifica for drugs and cosmetics is resolving these variations in lots. 11 Cosmetics Ingredients containing PUERARIA LOBATA ROOT EXTRACT. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. A comparative study on aqueous root extracts of Pueraria thomsonii and Pueraria lobata by antioxidant assay and HPLC fingerprint analysis. Iso Manufacturer Supply Natural Pueraria Lobata Extract Powder , Find Complete Details about Iso Manufacturer Supply Natural Pueraria Lobata Extract Powder,Pueraria Lobata Powder,Pueraria Lobata Extract from Herbal Extract Supplier or Manufacturer-Xian Pincredit Bio-Tech Co., Ltd.
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